MTHFR Endure - Physician Designed™
MTHFR Endure - Physician Designed™
MTHFR Endure - Physician Designed™
MTHFR Endure - Physician Designed™
MTHFR Endure - Physician Designed™
MTHFR Endure - Physician Designed™
MTHFR Endure - Physician Designed™
MTHFR Endure - Physician Designed™
MTHFR Endure - Physician Designed™

MTHFR Endure

Regular price $39.95

What is the difference between MTHFR Renew (formerly MTHFR Support) and MTHFR Endure (Formerly MTHFR Support Plus)?: MTHFR Renew uses a blend of 5-MTHF that supplements the need for folate. MTHFR Endure uses a gentler blend of folate and hydroxycobalamin which makes it a milder supplement between the two products. Depending on which genetic mutation of MTHFR you have, you may find using MTHFR Renew and MTHFR Endure separately or together works best. Ultimately, it is a personal preference of use and dosage. If you have not been tested for the MTHFR genetic mutation we recommend this test: Foundation Methylation Wellness Genetic Test

Which is best for me?

See blog post here. 

For New Users: MTHFR Endure is the best baseline support for MTHFR genetic errors as it was designed by utilizing intracellular vitamin and amino acid deficiencies. It has been observed in thousands of patients with diagnosed MTHFR (with no supplementation) since it fits into error pathways almost perfectly. 

Initially, start low and go slow by taking one capsule per day. Improved energy and mood should follow, however, if no difference is noted, increase to two capsules per day for a week. Repeat process and increase amount of capsules per day until you feel at the energy level you desire. Majority of patients take 2-3 capsules per day and a few take up to ten capsules daily.

Overmethylation: Overmethylation is a good sign you are taking too much MTHFR Support. Common side effects are sleepiness, drowsiness, and slight anxiety. If you experience these side effects, reduce the dosage back to previous level.

Warning: As a dietary supplement, take two capsules daily. Use as directed by your healthcare professional. When you find the right dosage of MTHFR to optimize your energy levels, do not miss a day as fatigue and ache pains will ensue the following days.

Store in a cool, dry place. Keep out of reach of children. 

Ingredients: Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Choline, Zinc, N-Acetyl L-Cysteine, Betaine Anhydrous, N-Acetyl L-Tyrosine, L-Serine, Rice Flour, Natural Flavor, Vegetable Capsules (Hypermellose [HPMC], purified water), Vegetable Magnesium Stearate

Clinically Proven

MTHFR Endure® is a registered trademark of Blue Sky Innovation, LLC

This product has not been evaluated by the Food and Drug Administration. It does not claim to treat or diagnose any illness or disease. 

Made in the USA

More Information: For more information, Dr. Purser's book on Amazon, 'The 85% Solution' covers MTHFR in detail.

Wholesale PricingMTHFR Endure is available at wholesale cost for physicians and practitioners, contact Brecken at for more details.

Subscribe & Save: Additional discounts/sales will not be applied when purchasing on a subscription service. 

Shipping: We ship our products domestically (free shipping on orders over $200) and internationally (based on UPS, USPS & DHL rates depending on size, weight, delivery speed, etc.). However, we reserve the right to cancel an order (with full refund) if destination country does not allow supplements in shipment. If you have any questions, please contact us at

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