What is Methylation?
The Folate Methylation Cycle is critical for the production of ATP (the currency cells utilize as energy). Certain genetic mutations passed down through generations cause deficiencies in the enzymes regulating this process. The most common mutation is the MTHFR (methylenetetrahydrofolate reductase) gene and its various versions. Some of these are the C677T or A2198C mutations on their corresponding chromosomal loci.
Genetic testing can be used to determine which, if any, mutations you may have. Heterozygous and homozygous variants of the genes can cause more intense symptoms of the MTHFR Genetic Mutation. Depending on which mutations you have, your general ATP production will be reduced compared to a “normal” genetic variant.
Which MTHFR Support Supplement is right for me?
Both MTHFR Support and MTHFR Support Plus are designed to bypass certain parts of the Methylation Cycle. Those with the MTHFR C677T genetic mutation cannot process Folate. Folate is a naturally occurring substance generally supplemented through diet. Additional folate with folic acid can become toxic to those with MTHFR mutations as they are ill-equipped to process it.
Instead, supplementing other parts of the Methylation Cycle (with 5-MTHF or with folinic acid) has shown great improvements to overall methylation function. Glucosamine Salt, or 5-MTHF, bypasses parts of the methylation cycle better for those with the C677T MTHFR Mutation than those with the A2198C. Folinic acid can be used as a less potent version of 5-MTHF but still have great effects for those with the A2198C mutation.
MTHFR Support is designed for those suffering from the Homozygous C677T MTHFR genetic mutation disease. This is the most devastating of the MTHFR genetic disorders, causing exhaustion, depression, and anxiety as cells struggle to produce any ATP. This is the supplement that most people start on until they start to feel the effects of overmethylation. At that point, many reduce dosage or begin using MTHFR Support Plus for a time. Finding a balance requires time and personal preference. For this reason, many patients use MTHFR Support and MTHFR Support Plus.
MTHFR Support Plus
MTHFR Support Plus was originally designed as a go-to product for anyone with any type of MTHFR Genetic Mutation. It utilizes folinic acid instead of 5-MTHF as the main folate supplement. Folinic acid appears earlier in the Methylation Cycle and can have strong effects for those with the MTHFR A198C error. The MTHFR Support Plus is generally used as the less potent version between MTHFR Support and MTHFR Support Plus.
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