Brain Support MicroPQQ® & MicroActive® CoQ10

Promotes Brain & Heart Health

$59.95 USD
What is Brain Support?

An ideal dietary supplement with powerful effects to combat the onset and symptoms of normal cognitive decline associated with aging.

Pyrroloquinoline Quinone (PQQ) is a novel cofactor capable of repeated oxidation and reduction reactions for thousands of cycles, influencing cell-signaling pathways important to mitochondrial function.  In particular, it affects mitochondrial oxidative metabolism, antioxidant defense, and inflammation.  PQQ stimulates the spontaneous growth of new mitochondria in aging cells, and activates genes that govern mitochondrial reproduction, protection, and repair.  PQQ has been found to be effective in combating the onset of certain types of mental and cognitive impairment that is a normal part of aging, and even restoring certain higher mental functions such as short-term memory and focus. 

The biochemical properties of PQQ are similar to vitamin C in its oxidation-reductive potential, to riboflavin in its redox effects, and to vitamin B6 as a coenzyme for carbonyl group chemistry.

Studies show that PQQ facilitates nerve regeneration and enhances nerve growth factor through its function as an ultrapotent antioxidant (Urakami T). By increasing the number and efficiency of mitochondria, PQQ helps brain cells function more effectively.

In one study, PQQ exerted an improvement in cerebral function. Improvements were also found in high-level cerebral functions, including attention and information-discriminating and processing abilities, more so than of memory. PQQ and PQQ with CoQ10 improved high-level cerebral functions in healthy middle-aged and older adults.

MicroActive® CoQ10:

Is three times better absorbed than regular (crystalline) CoQ10.

Is two times better absorbed than solubilized (enhanced bioavailability) CoQ10 softgels.

Doubles CoQ10 levels from baseline after three weeks in 100% of users.

MicroPQQ®:

Protects nerve cells

Improves cognitive function

Alleviates occasional stress and sleeplessness

Studies have shown up to a 30 times improvement in short-term memory and focus in cognitive evaluation testing on persons 50-70 years old who exhibited mild memory loss associated with aging when taking one daily dose of PQQ and CoQ10 together.  PQQ supplementation has been shown to improve high-level functions including attention and discriminating and processing abilities.

PQQ inhibits amyloid fibril formation of amyloid proteins, presenting the possible benefits of a novel therapeutic approach to neurodegenerative diseases.

For New Users

Take two capsules orally a day. Use as directed by your healthcare professional.

Ingredients

Vegetarian capsule (hypromellose), cellulose, rice bran flour, metolose, beta-cyclodextrin (or non-GMO potato starch), carnuaba wax (plant extract).

Warning

This product and statement, "Brain Support," has not been approved by the FDA. It does not claim to diagnose or treat any illness or disease. 

MicroPQQ® and MicroActive® are registered trademarks of Bioactives, LLC. 

Made in the USA

References

Urakami T, Tanaka A, Yamaguchi K, Tsuji T, Niki E. Synthesis of esters of coenzyme PQQ and IPQ, and stimulation of nerve growth factor production. Biofactors (Oxford, England). 1995-1996;5(3):139-146. PMID: 8922270.

He K, H. Nukada, T. Urakami, M.P. Murphy. Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems. Biochem Pharmacol. 2003; 65: 67–74

Koikeda T, M. Nereno, and K. Masuda. Pyrroloquinoline quinone disodium salt improves higher brain function. Medical Consultation & New Remedies. 2011; 48(5): 59-67.

Nakano M, K. Ubukata, T. Yamamoto, H. Yamaguchi. Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. FOOD Style 21. 2009; 13(7): 50–3.

Madhavi D, Kagan D. Integrative Med. 2010 Feb/Mar;9(1):20-4.

Chowanadisai W, M. Nakano. Potential physiological importance of pyrroloquinoline
quinone. Altern Med Rev. 2009; 14(3): 268–77.

Chowanadisai W, K.A. Bauerly, E. Tchaparian, A. Wong, G.A. Cortopassi, R.B. Rucker.
Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response
element-binding protein phosphorylation and increased PGC-1 alpha expression. J Biol
Chem. 2010; 1285(1): 142–52.

Harris C, et al., Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation
and mitochondrial-related metabolism in human subjects. Journal of Nutritional
Biochemistry. 2013; 24: 2076–2084.

He K, H. Nukada, T. Urakami, M.P. Murphy. Antioxidant and pro-oxidant properties of
pyrroloquinoline quinone (PQQ): implications for its function in biological systems.
Biochem Pharmacol. 2003; 65: 67–74.

Koikeda T, M. Nereno, and K. Masuda. Pyrroloquinoline quinone disodium salt improves
higher brain function. Medical Consultation & New Remedies. 2011; 48(5): 59-67.

Kumazawa T, K. Sato, H. Seno, A. Ishii, O. Suzuki. Levels of pyrroloquinoline quinone in
various foods. Biochem J. 1995; 15(307 Pt 2): 331–3.

Nakano M, K. Ubukata, T. Yamamoto, H. Yamaguchi. Effect of pyrroloquinoline quinone
(PQQ) on mental status of middle-aged and elderly persons. FOOD Style 21. 2009; 13(7):
50–3.

Nakano M, et al. Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress,
Fatigue, and Sleep. Functional Foods in Health and Disease. 2012; 2(8): 307–24.

Rucker R, A. Ouchi, I. Nakano, S. Nagaoka, K. Mukai. Kinetic study of the antioxidant activity
of pyrroloquinoline quinol (PQQH2, a reduced form of pyrroloquinoline quinone) in
micellar solution. J Agric Food Chem. 2009; 57: 450–56.

Stites TE, A.E. Mitchell, R.B. Rucker. Physiological importance of quinoenzymes and the
O-quinone family of cofactors. J Nutr. 2000; 130(4): 719–27.

Wholesale Pricing

VARS Mint Burst Glutathione is available at wholesale cost for physicians and practitioners, contact Brecken at brecken@aespmi.comfor more details.

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Shipping

We ship our products domestically (free shipping on orders over $200) and internationally (based on UPS, USPS & DHL rates depending on size, weight, delivery speed, etc.). However, we reserve the right to cancel an order (with full refund) if destination country does not allow supplements in shipment. If you have any questions, please contact us at info@physiciandesigned.com.

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