$39.95 USD

27 reviews

What is the different between MTHFR Endure and MTHFR Renew?
MTHFR Renew uses a blend of 5-MTHF that supplements the need for folate. MTHFR Endure uses a gentler blend of folate and hydroxocobalmin which makes it a milder supplement between the two products. Depending on which genetic mutation of MTHFR you have, you may find using MTHFR Renew and MTHFR Endure separately or together works best. Ultimately, it is a personal preference of use and dosage. If you have not been tested for the MTHFR genetic error, we recommend the test 'Foundation Methylation Wellness Genetic Test' found at

For New Users

MTHFR Renew is the best baseline support for MTHFR genetic errors as it was designed by utilizing intracellular vitamin and amino acid deficiencies. It has been observed in thousands of patients with diagnosed MTHFR (with no supplementation) since it fits into error pathways almost perfectly. It is different from MTHFR Endure as it contains folate from a much higher dose of 5-MTHF.

Initially, start low and go slow by taking one capsule per day. Improved energy and mood should follow, however, if no difference is noted, increase to two capsules per day for a week. Repeat process and increase amount of capsules per day until you feel at the energy level you desire without overmethylating. Majority of patients take 2-3 capsules per day and a few take up to ten capsules daily.

Overmethylation is a good sign you are taking too much MTHFR Renew. Common side effects are sleepiness, drowsiness, and slight anxiety. If you experience these side effects, reduce the dosage back to previous level.


Stabilized rice grain, vegetarian capsule (hypromellouse), magnesium stearate

More Information

For more information, Dr. Purser's book on Amazon, 'The 85% Solution' covers MTHFR in detail.

Clinically Proven, Patent Pending

MTHFR Renew® is a registered trademark of Blue Sky Innovation, LLC

This product has not been evaluated by the Food and Drug Administration. It does not claim to treat or diagnose any illness or disease.

Made in the USA


Consult medical advice from primary physician before use.

Wholesale Pricing

MTHFR Renew is available at wholesale cost for physicians and practitioners.

Contact us at for more details.

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We ship our products domestically (free shipping on orders over $200) and internationally (based on UPS, USPS & DHL rates depending on size, weight, delivery speed, etc.). However, we reserve the right to cancel an order (with full refund) if destination country does not allow supplements in shipment. If you have any questions, please contact us at

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